The Cathedral Church of St Mary is a Catholic cathedral in Newcastle upon Tyne, Tyne and Wear, England.

The cathedral, situated on Clayton Street, was designed by Augustus Welby Pugin and built between 1842 and 1844. The cathedral is a fine example of the Gothic Revival style of architecture championed by Pugin.

There is a monument dedicated to Cardinal Basil Hume in the Monument Garden outside of the cathedral, which was opened by Queen Elizabeth II in 2002.